Unveiling the Depths: Exploring the Pervasive Impact of Untreated Depression and the Revolutionary Potential of TMS Therapy

Mar 1, 2024 | Best Practices, Medication, Mental Health, TMS Therapy

“TMS Therapy is enlightening because it’s almost like a whole weight is lifted off you because you feel lighter and you have a whole lot more to look forward to.” -Sarah. TMS Patient


Embarking on a mental health journey, this blog uncovers how untreated depression profoundly impacts the brain. Recent research reveals persistent depression’s influence on vital brain regions, altering cognition and emotions. We scrutinize the effects on the hippocampus, thalamus, amygdala, and prefrontal cortex, exploring potential solutions for those wrestling with clinical depression.

The Brain’s Vulnerability:

Brain mapping image

1. Unveiling the Hippocampus: Discoveries from the National Institute of Mental Health: Reduction in hippocampal volume links to untreated depression, impairing memory and emotional regulation, contributing to cognitive deficits.

2. Thalamus in Turmoil: Insights from the Journal of Psychiatric Research: Altered thalamic connectivity in untreated depression, potentially explaining disruptions in sleep, perception, and cognitive function in chronic cases.

3. Amygdala Amplified: Highlighted by the American Journal of Psychiatry: Hyperactivity in the amygdala during untreated depression leads to increased anxiety and challenges in emotion regulation.

4. Prefrontal Cortex Diminished: Biological Psychiatry’s findings: Decreased prefrontal cortex activity in prolonged depression impacts decision-making and impulse control, resulting in difficulties with concentration and goal-directed behavior.

Understanding Clinical Depression:

Persistent feelings of hopelessness, fatigue, appetite changes, and disrupted sleep extend beyond occasional sadness. Early recognition is crucial for intervention, hindering normal functioning and enjoyment of daily life.

Treatment Beyond Conventions:

In the landscape of treating depression, traditional methods like psychotherapy and medication have been stalwarts. However, a notable paradigm shift is occurring with the emergence of Transcranial Magnetic Stimulation (TMS) therapy. While psychotherapy delves into the roots of psychological distress and medication addresses chemical imbalances, TMS offers a unique and innovative approach.

The Evolution of Treatment:

Therapist and patient having a happy conversation
  1. Psychotherapy: Traditional talk therapies, while valuable, may require time to uncover and address underlying issues contributing to depression. The journey involves dialogue, introspection, and a collaborative effort between the individual and the therapist.
  1. Medication: Antidepressant medications, commonly prescribed, work by altering neurotransmitter levels in the brain. While effective for many, they may come with side effects, and finding the right medication and dosage can be a trial-and-error process.

The TMS Paradigm:

Brainsway helmet

TMS introduces a groundbreaking approach. By utilizing magnetic fields to stimulate specific brain regions, particularly the prefrontal cortex, it offers a non-invasive, precise, and targeted intervention. Unlike medication, TMS doesn’t circulate throughout the entire body, minimizing side effects often associated with traditional pharmaceutical treatments.

TMS has demonstrated efficacy even in cases resistant to conventional treatments. Studies published in Future Psych Solutions showcase its potential to modulate neural circuits associated with depression, providing a glimmer of hope for those who have found little relief elsewhere.


Untreated depression transcends fleeting emotions, reshaping the brain and impairing cognitive function. Recognizing signs is crucial, as is exploring innovative treatments like TMS therapy – a promising avenue for lasting relief in the silent battle against depression.

Are you or someone you know, suffering from Clinical Depression? Leaving depression untreated can be detrimental to your brain’s long term health. See how TMS therapy can help you find relief from your depression, even remission, with Manuel Austruc M.D. Call or text us today!